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17-AAG

Description

17-Allylamino-17-demethoxygeldanamycin (17-AAG) is an analogue chemically derived from GA. 17-AAG is a less toxic and more stable analogue of geldanamycin (GA). Even though 17-AAG binding to Hsp90 is weaker than GA, 17-AAG displays similar antitumor effects as GA and a better toxicity profile. 17-AAG is currently in phase I clinical trial in several centers worldwide. Preliminary data obtained from these trials demonstrate that antitumor activity is achieved at concentrations below the maximum tolerated dose.

Formula: C31H43N3O8

Molecular weight: 585.69

CAS Number : 75747-14-7

Appearance:  purple powder

Geldanamycin derivated at the 17^th position to yield
17AAG